• br Acknowledgment This work was supported by National Natura

  2020-08-03

  

  Acknowledgment This work was supported by National Natural Science Foundation of China (Grant No. 41606122), and Natural Science Foundation of Zhejiang Province (LY15C190009). Introduction Human immunodeficiency virus (HIV)-protease inhibitor (PI)-based highly active antiretroviral therapy (H

• br Experimental br Acknowledgments The

  2020-08-03

  

  Experimental Acknowledgments The work was supported in part by the National Research and Development Plan (2017YFD0200506), the National Natural Science Foundation of China (21472062 and 31701820), 111 Project B17019, and excellent doctoral dissertation cultivation Grant from Central China Nor

• Both receptors belong to the large family of G

  2020-08-03

  

  Both receptors belong to the large family of G protein-coupled receptors (GPCRs) [4,5], which often appeared as monomers, dimers and higher order aggregates [6,7]. There is evidence that these receptor-complexes can modulate the functionality and the pharmacology of the receptors [8,9] by sequester

• The cellular sources of inflammatory

  2020-08-03

  

  The cellular sources of inflammatory cytokines enhanced in chronic renal failure patients are mainly neutrophils and monocytes [10]. Although the distinct mechanisms for the induction of leukocyte apoptosis remain uncertain, oxidant stress has been suggested as a major triggering factor. Our results

• Recent advances in computational biology have facilitated th

  2020-07-31

  

  Recent advances in computational biology have facilitated the identification of EREs in many gene promoters, and allowed prediction of genes regulated by MRS 1220 and other hormones in the genomes of many species (Bajic et al., 2003; Bourdeau et al., 2004). A recent genome-wide screening study iden

• br Materials and methods br Results br

  2020-07-31

  

  Materials and methods Results Discussion In terms of MFI levels, only the CD45−CD34 + CXCR7+ cells significantly and negatively correlated with NSE concentrations. This finding seems especially interesting in the light of the results of our recent study and the newest reports of other resea

• LB-100 Pursuant to our in vitro data that neutrophilic elast

  2020-07-31

  

  Pursuant to our in vitro data that neutrophilic elastase activated the elastase-dependent oncolytic virus, we initially hypothesized that tumor-infiltrating neutrophils could be the source for elastase in tumor tissue. However, we did not detect neutrophils in the PANC-1 tumor tissue where we observ

• The phosphorylation S of Syn plays a key

  2020-07-31

  

  The phosphorylation (S129) of αSyn plays a key role in αSyn-related cell death (Sugeno et al., 2008). The activation of eIF2a is known to be a trigger of apoptosis (Hoozemans et al., 2007). The phosphorylation of eIF2a promotes translation of activating transcription factor 4 messenger RNA. Subseque

• For mounting an effective immune response by

  2020-07-31

  

  For mounting an effective immune response by secretion of pro- or anti-inflammatory mediators and phagocytosis of invading pathogens or cellular debris during an infection, deployment of specific subsets of macrophages to the site of inflammation must be temporally and spatially strictly regulated.

• From our mutational studies we found that both the N

  2020-07-31

  

  From our mutational studies, we found that both the N- and C-terminal Zn-finger motifs are indispensable for the activity of LNX1, unlike LNX2, which only requires the N-terminal motif for function [24]. To our knowledge, this is the first reported case where two Zn-finger motifs are necessary for R

• GSK2126458 Among the discovered structures the G structure

  2020-07-31

  

  Among the discovered structures, the G4 structure has gained significant attentions for its emerging role in key processes such as replication, transcription and telomere maintenance.5, 6, 7 Due to its potential as a therapeutic target, G4 has been the object of intense studies, and a significant nu

• With regard to genetics we

  2020-07-31

  

  With regard to genetics, we found that COMT Val158Met predicted successful fear and mln4924 recall on Day 2 as measured with fear bradycardia and the LPP. At the beginning of the recall test, one day after conditioning and extinction, Val homozygotes but not Met carriers showed significantly enhance

• In an oral lipid tolerance test OLTT

  2020-07-30

  

  In an oral lipid tolerance test (OLTT), fasted rats were administered compound at a range of doses 2h prior to a carnitine palmitoyltransferase dose of corn oil and plasma TAG levels were measured 1.5h later. shows that was highly efficacious in reducing plasma TAG excursion in this model, exhib

• Alternatively receptors may be customized to

  2020-07-30

  

  Alternatively, receptors may be customized to fulfill novel tasks, as has been demonstrated for the modular extracellular sensor architecture (MESA) receptors that enable aqz to sense vascular endothelial growth factor (VEGF) and, in response, secrete IL-2 [94]. MESA receptors are composed of a tar

• QS 11 In this study we describe the

  2020-07-30

  

  In this study, we describe the development of a new animal model that can be used to pharmacologically evaluate the efficacy of CysLT1 and CysLT2 receptors antagonists on anaphylactic response in vivo. In our experiments, we examined whether antigen-induced QS 11 in sensitized guinea pigs is altered

16186 records 810/1080 page Previous Next First page 上5页 806807808809810 下5页 Last page