• Measured physicochemical water parameters including

  2021-10-27

  

  Measured physicochemical water parameters including conductivity, suspended solids and nutrient load along the studied sites (Table 1) were high compared to levels usually found in undisturbed rivers within Europe (Chapman and Kimstach, 1996). In particular conductivity, suspended solids and phospha

• Since KYNA concentrations are increased by aerobic exercise

  2021-10-27

  

  Since KYNA concentrations are increased by aerobic exercise training, we have investigated if it plays a role in peripheral tissue metabolism. Here we show that KYNA regulates adipose tissue energy homeostasis through activation of Gpr35. Activation of this network stimulates the expression of lipid

• Our data for glucose and insulin tolerance tests

  2021-10-27

  

  Our data for glucose and insulin tolerance tests indicate that niacin-induced hyperglycemia is proportional to the degree of insulin resistance induced, implying that there is deterioration in islet function with niacin treatment (McCulloch et al., 1991). In this regard, we have demonstrated, for th

• Transcriptional translational modulators The discovery that

  2021-10-27

  

  Transcriptional/translational modulators. The discovery that β-lactam antibiotics like ceftriaxone enhance the in vivo expression of EAAT2/GLT-1 [31] has pioneered a completely new approach to EAAT modulation, with several additional EAAT activators following in its trail (Figure 2b) [32, 33, 34•, 3

• Because sleep and metabolism are intimately linked the autho

  2021-10-27

  

  Because sleep and metabolism are intimately linked, the authors next move to study whether Eaat2 also controls metabolic rate. First, we must ask how sleep and metabolism are connected at a functional level. The (-)-Quinpirole hydrochloride allocation hypothesis of sleep posits that organisms tempo

• br Results br Discussion Arc p forms a

  2021-10-27

  

  Results Discussion Arc1p forms a ternary complex with ScMetRS and ScGluRS and acts as a tIF in trans of both synthetases to improve their catalytic efficiencies.20., 24. The human homolog of Arc1p, the p43 protein, is associated within a multi-enzyme complex containing nine aminoacyl-tRNA synt

• Bardoxolone methyl br Ghrelin Ghrelin was purified from rat

  2021-10-27

  

  Ghrelin Ghrelin was purified from rat stomach about twenty years ago as a 28-amino Bardoxolone methyl octanoylated peptide and shown to be the endogenous ligand of the growth hormone (GH) secretagogue receptor (now termed GHSR1a, Howard et al., 1996, Kojima et al., 1999). GHSR1a is a 7-transmemb

• Inhibitors of the G rdos effect include the Ca

  2021-10-27

  

  Inhibitors of the Gárdos effect include the Ca2+-channel blocker nitrendipine with an IC50 of ∼103nM (Ellory et al., 1992, Ellory et al., 1992); its mode of action is likely to be from direct blockage of K+ flux through the Gárdos channel (Ellory et al., 1992, Ellory et al., 1992), and the peptidic

• To improve the preferential GalR binding

  2021-10-27

  

  To improve the preferential GalR2 binding, we synthesized M1152 where the N-terminal Gly residue was deleted, in analogy with previously designed M871 (Sollenberg et al., 2006). In addition to the poor affinity of M871 for GalR1, a recent study showed that it also hardly recognized by GalR3 (Sollenb

• Computational approaches such as docking and classical

  2021-10-27

  

  Computational approaches such as docking and classical molecular dynamics (MD) are now commonly used to study the structure and dynamics of proteins as well as associated protein-ligand interactions [12]. A fundamental requirement of MD in order to accurately determine the behavior of a protein over

• In the present study we focused

  2021-10-26

  

  In the present study, we focused on a role of the C-terminal segment in GCAP2 using two chimeric proteins, in which the C-terminal segment of GCAP2 was either replaced by the corresponding sequence of recoverin (chimera GR) or transferred into recoverin (chimera RG). We have monitored Ca-dependent c

• Using embelin and its analogs as surrogate GPR agonists

  2021-10-26

  

  Using embelin and its analogs as surrogate GPR84 agonists we discovered that GPR84 couples to G12 and G13 signaling pathways in addition to Gi, linking receptor function to Rho/Rac signaling and modulation of the cytoskeleton. In primary human macrophages, GPR84 activation leads to Gβγ signaling, E

• Elimination of the Q R bridge significantly affected the pro

  2021-10-26

  

  Elimination of the Q234–R244 bridge significantly affected the protein 4-DAMP sale but had little effect on its activity at a permissive temperature, which may seem contrary to the known functional importance of this motif in Fpg. However, since the mutants fully or partially retained the bound zin

• Attempting to further elucidate the role

  2021-10-26

  

  Attempting to further elucidate the role of p0035 and activation of the Gcgr without the influence of GLP-1, we used DT-Gcg mice with acute knockdown of all proglucagon products. This mouse model has previously been shown previously to have a normal total islet area as well as β cell area compared

• Initially we carried out gap FRAP

  2021-10-26

  

  Initially, we carried out gap-FRAP experiments using the two-photon configuration of the confocal microscope. A SR101-positive astrocyte was targeted and a 5 × 5 μm square area was exposed to a laser illumination (5 flashes of 5 s each during 25 s). This procedure resulted in a bleaching of this ast

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