• br Discussion In the present study

  2022-05-07

  

  Discussion In the present study, we have demonstrated the effect of a high-fat diet upon wild-type and glut3 pregestational female phenotype and shown that it leads to obesity due to an increase in white adipose tissue contributing to the overall fat mass. Despite this observed obesity along with

• A key limiting factor in the

  2022-05-07

  

  A key limiting factor in the semi-quantitative analysis of changes in the nuclear-to-cytoplasmic distribution of glucokinase is the large intercellular heterogeneity of Clofibric Acid receptor of glucokinase in both isolated hepatocytes in vitro and also in liver in vivo[13], [23], [24], [26], [36]

• Introduction Erythrocyte membrane proteins or

  2022-05-07

  

  Introduction Erythrocyte membrane proteins or their orthologs are found in almost all Donitriptan hydrochloride sale of the body [1,2]. Because of this compositional similarity and the erythrocyte membrane's accessibility, the red blood cell membrane (RBCM) has served as a crude model for mammalian

• A majority of investigations of the GCK

  2022-05-07

  

  A majority of investigations of the GCK-PFK-2/FBPase-2 interaction have taken place within cells. Immunofluorescence studies in several fixed cell lines indicate that GCK colocalizes with PFK-2/FBPase-2 in the cytoplasm following overexpression [[68], [69], [70]]. Live cell imaging conducted on CD 2

• br Results br Discussion ER and GR

  2022-05-07

  

  Results Discussion ER and GR play opposite phenotypic roles in the normal endometrium, with ER promoting growth and GR inhibiting growth. Here, we show that in endometrial cancer, GR expression is associated with worse outcomes and higher-grade tumors, and this association is observed only in

• Our data suggest that Slc a is important for

  2022-05-07

  

  Our data suggest that Slc38a5 is important for amino-acid-induced α cell proliferation and expansion of α cell mass following GCGR inhibition, but not for formation and maintenance of α cell mass. This is supported by the finding that Slc38a5−/− mice have normal α cell mass. This is interesting sinc

• We have isolated various bioactive peptides acting by bindin

  2022-05-07

  

  We have isolated various bioactive Hexa His acting by binding to the receptors of endogenous bioactive peptides such as opioid, bradykinin, neurotensin, and complements C3a and C5a etc. [24]. Rubimetide is the first example of an agonist peptide of the FPR2 of exogenous origin. Anxiolytic-like act

• Brain derived neurotrophic factor BDNF is the most

  2022-05-07

  

  Brain-derived neurotrophic factor (BDNF) is the most abundant growth factor in the brain and is critical for neuronal development and synaptic plasticity (Bekinschtein et al., 2008; Lu et al., 2014). Besides playing an important role in mood and cognition, BDNF is also involved in the regulation of

• Pharmacological inhibition of PKR seems to be an

  2022-05-07

  

  Pharmacological inhibition of PKR seems to be an interesting strategy for revealing the role of PKR in oxytosis and ferroptosis. The oxindole/imidazole derivative C16 was identified by screening a library of 26 different ATP-binding site-directed inhibitors of varying structure that is more selectiv

• br Clinical assessment of iron chelation

  2022-05-07

  

  Clinical assessment of iron chelation Towards the new concept of conservative iron chelation: iron scavenging and redeployment For any chelator to be of clinical value in disorders of regional siderosis they ought to be endowed with a requisite accessibility to the relevant sites and different

• QX 314 bromide The more important effect of pitolisant is re

  2022-05-06

  

  The more important effect of pitolisant is related to its wake-promoting and arousal activities as a result of enhanced QX 314 bromide release in animal models (Ligneau, Perrin, et al., 2007). Moreover, its potential in the treatment of severe excessive daytime sleepiness (EDS) in narcoleptic teena

• Arena Pharmaceutical introduced a biaryl sulfone derivative

  2022-05-06

  

  Arena Pharmaceutical introduced a biaryl sulfone derivative with antagonistic activity at H3Rs known as APD-916, ((R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine), which was rationally designed from corresponding sulfonamides in order to yield compounds with short dura

• Introduction Cancer has been a significant public health

  2022-05-06

  

  Introduction Cancer has been a significant public health problem in the world with more patients being diagnosed every year. However, chemotherapy from non-specific cytotoxic agents that as an effective means of cancer treatment is limited by severe side effects and poor selectivity. Thus, the deve

• br Authors contribution br Funding sources This study was su

  2022-05-06

  

  Authors' contribution Funding sources This study was supported by CDC intramural funding. Publication costs are funded by an internal program of CDC. MAT was supported by funds from the Association of Public Health Laboratories and CDC (APHL–CDC) Bioinformatics Fellowship Program. Competing

• Pancuronium dibromide In order to better manage HBV infectio

  2022-05-06

  

  In order to better manage HBV infection and related liver diseases, it is critical to develop new antiviral strategies to increase the rate of functional or complete cure of HBV infection (HBsAg loss and cccDNA elimination), achieving more than viral suppression (Zeisel et al., 2015). As a result, m

16187 records 448/1080 page Previous Next First page 上5页 446447448449450 下5页 Last page