• However these limitations should not detract from the

  2018-11-09

  

  However, these limitations should not detract from the novel and innovative study presented by . Indeed the evidence from this study demonstrates that repeat sub-concussive head impacts affect the brain physiologically. These findings not only translate to clinical practice, where physicians and phy

• br Beyond extinction cognitive forms of fear regulation

  2018-11-09

  

  Beyond extinction: cognitive forms of fear regulation While the efficacy of exposure-based CBT depends on the ability of a given individual to acquire and retrieve extinction memories (Berry et al., 2009), cognitive strategies can also be employed to regulate conditioned fear responding. Standard

• It has been noted however that while the

  2018-11-09

  

  It has been noted, however, that while the process model focuses mainly on implementation success (or failure) of particular emotion regulation strategies, adaptive emotion regulation actually involves a broader repertoire of skills, including flexible strategy selection (e.g. Bonanno and Burton, 20

• br Conclusion We designed and manufactured a portable smartp

  2018-11-09

  

  Conclusion We designed and manufactured a portable smartphone holder and myc pathway LFA strip to produce a smartphone-based measurement system. Salivary cortisol concentration serves as a biomarker of psychological stress. Because physiological cortisol is secreted in a circadian rhythmic manne

• To generate energy for nanoscale systems ZnO

  2018-11-09

  

  To generate energy for nanoscale systems, ZnO based piezoelectric nanogenerators are an ideal source, especially in the case of small size and low power consumption batteries with a long life time. For a sustainable independent operation, a continuous power source is required and for this type of op

• En este escenario global M

  2018-11-09

  

  En este escenario global, México tiene ante sí el reto histórico de trascender su condición de país atrasado en el concierto internacional, y que ante la fallida estrategia de industrialización por sustitución de importaciones, lo llevó a integrarse a través del tlcan en los eslabones bajo y medio d

• br Conclusions Sitosterol d glucoside and five condensed

  2018-11-08

  

  Conclusions β-Sitosterol-d-glucoside (1) and five condensed tannin fractions (2, 3, 4, 5, and 6) were isolated from the leaves of Q. phillyraeoides. The α-glucosidase inhibitory and antioxidant activities of the isolated constituents were investigated. Four antioxidant assays were successfully co

• Nodal Activin signaling is an evolutionarily conserved signa

  2018-11-08

  

  Nodal/Activin signaling is an evolutionarily conserved signal transduction pathway, and plays critical roles in the maintenance and differentiation of hESCs. Nodal and Activin (Activin A and Activin B [Thompson et al., 2004]) are members of the transforming growth factor beta (TGFβ) superfamily, and

• Previous studies demonstrated SPION labeling

  2018-11-08

  

  Previous studies demonstrated SPION-labeling in a variety of human (Niemeyer et al., 2010; Song et al., 2007) and animal (Rice et al., 2007; Zhu et al., 2007) stem cells. We used SPION to track MSC in the QUIN model. SPION were internalized in MSC without affecting cellular viability. These data cor

• V ATPases is a pH

  2018-11-08

  

  V-ATPases is a pH regulator in acidic subcellular compartments including the Golgi complex, vesicles, and lysosomes. Wnt3a secretion requires its binding to the carrier protein wntless (WLS) and Wls-dependent secretion of Wnt3a was shown to require vacuolar acidification (Coombs et al, 2010). In the

• Genetically engineered stem cells may have an

  2018-11-08

  

  Genetically engineered stem cells may have an advantage for gene therapy due to their inherent migration to tumor sites (Kang et al., 2012a; Kang et al., 2012b; Kang et al., 2012d). In this study, we employed HB1.F3 human neural stem cells (hNSCs) obtained from 15week fetal telencephalon and immorta

• Previous studies have demonstrated that the signal transduct

  2018-11-08

  

  Previous studies have demonstrated that the signal transduction pathways mediating ATF3 expression include c-Jun co-expressed with ATF3 in the nervous system after injury and stress (Hunt et al., 2012). The selective JNK/c-Jun inhibitor SP600125 fully blocks ATF3 induction in adult rat ganglion neur

• Sustained constitutive activation of Notch signaling or

  2018-11-08

  

  Sustained, constitutive activation of Notch1 signaling or stimulation with the Jagged1 soluble ligand maintains long-term proliferation of cultured cardiomyocytes, delaying their differentiation into mature beating cells (Boni et al., 2008). This phenomenon should not be interpreted as cell dediffer

• cytotoxicity assay br Conclusions The data presented here

  2018-11-08

  

  Conclusions The data presented here demonstrate that MSX2 induces dedifferentiation with partial cell cycle re-entry in postmitotic multinucleated mammalian muscle cells. Our pharmacological treatment recapitulates MSX2-induced dedifferentiation and exhibits potential for future therapeutic proto

• Keeping SCs out of the

  2018-11-08

  

  Keeping SCs out of the active (-)-p-Bromotetramisole Oxalate Supplier phase and minimizing the risk of DNA damage may be especially important in aging and has led to a SC hypothesis of aging (Sharpless and DePinho, 2007; Beausejour and Campisi, 2006). We succeeded in transiently inhibiting DREAM ex

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