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Programmed death ligand PD L expression is a
2019-06-14
Programmed death ligand 1 (PD-L1) expression is a characteristic feature of EBV-associated malignancies. Research has shown that an increase of PD-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma. Preliminary data from a phase Ib study, KEYNOTE-028, showed
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Paying now rather than forever has never been
2019-06-14
Paying now rather than forever has never been as relevant as a global health solution to the HIV pandemic than in 2013. The relative success of the ongoing replenishment session for the Global Fund is a positive signal, although still insufficient considering the evidence-based targets that are set
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This study addresses an important
2019-06-14
This study addresses an important question about whether routine clinic follow-up after medical abortion can be responsively eliminated from service delivery protocols, thus reducing a key barrier to accessing medical abortion. Such a service change could be especially beneficial for women in rural,
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br La desaparici n de los aquechistas Las pr
2019-06-14
La desaparición de los aquechistas Las prácticas contrainsurgentes desatadas por el conflicto interno guatemalteco de la administración del general Kjell Eugenio Laugerud García (1974-1978), golpearon EAI045 diversos actores de la usac. Ejemplo de ello fue el asesinato del abogado Mario López Lar
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El primero corresponde al Frente Guerrillero Edgar Ibarra fg
2019-06-14
El primero corresponde al Frente Guerrillero Edgar Ibarra (fgei), grupo perteneciente natriuretic peptide receptor las Fuerzas Armadas Rebeldes (far) de Guatemala, que inició operaciones en 1962 en la sierra de Zacapa, y que en enero de 1966 fue objeto de un amplio fotorreportaje publicado en la rev
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To facilitate WHO s goals it is important to assess
2019-06-13
To facilitate WHO\'s goals, it HG-9-91-01 is important to assess the cost-effectiveness of interventions that incorporate emerging technologies for case detection, treatment, and vector control in the context of economic constraints and logistical barriers. In an elegant modelling study in , Simone
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Thomas Hoeksema por su parte explica
2019-06-13
Thomas Hoeksema, por su parte, explica la paradoja del título del siguiente modo: “la destrucción (fuego) está moderada por la estabilidad y la armonía (reposo). La relación entre estas dos fuerzas es multidimensional y dialéctica”. Para Hoeksema, el segundo volumen poético de Pacheco se debe entend
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The increasing burden of NCDs poses
2019-06-13
The increasing burden of NCDs poses an enormous threat to populations and health systems across the globe. The Sustainable Development Goals represent an important opportunity to integrate efforts to reduce the burden of NCDs and promote sustainable development. The recent identification of NCDs as
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The primary tool in the pharmacological
2019-06-12
The primary tool in the pharmacological management of PTSD is the use of selective serotonin reuptake inhibitors [55,56], but positive response rates are generally limited. In addition, non-pharmacological treatment such as CBT has been shown to be effective for PTSD [57]. Psychological distress
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Cardiac fibroblasts express various ion channels in
2019-06-12
Cardiac fibroblasts express various ion channels, in particular voltage-gated K focal adhesion kinase and nonselective cation channels of the transient receptor potential (TRP) family . Both K and TRP channels are important determinants of fibroblast function, with TRP channels acting as Ca entry p
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br Case report Radiographs showed a lytic lesion in
2019-06-12
Case report Radiographs showed a lytic lesion in the left ilium adjacent to the sacroiliac joint (Fig. 1). Computed tomography (CT) (Fig. 2) showed a 5.5×5.0×3.4cm3 lytic lesion in the left ilium; the sacrum was not involved. The lesion was of uniform density with no bone or cartilage matrix form
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In their analysis the investigators did not include
2019-06-12
In their analysis, the investigators did not include common causes of CKD in sub-Saharan Africa other than HIV, diabetes, and hypertension—notable omissions were chronic glomerulonephritis and use of herbal or traditional treatments. Also, communicable diseases might contribute substantially to CKD
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br Ogolpe militar do dia de setembro de no
2019-06-12
Ogolpe militar do dia 11 de setembro de 1973, no Chile, destituiu do poder o então presidente Salvador Allende, eleito em 1970 pela Unidad Popular (up), coalizão política composta por partidos de esquerda que propunham glucocorticoid receptors “via chilena para o socialismo”. De acordo com Priscil
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br Possible reasons for the divergent results for the predic
2019-06-11
Possible reasons for the divergent results for the predictive value of PES for cardiac events First, there were methodological differences in the stimulation protocols used for PES, including the number of extrastimuli, the minimum coupling interval used (up to 200ms or refractoriness), the site
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acetanilide The benign exostoses in TRPS have a recognized m
2019-06-11
The benign exostoses in TRPS have a recognized malignant potential which have been shown to develop into chondrosarcomas [4,13]. Both our index case and his mother demonstrated de novo high grade osteosarcoma. To our knowledge, this occurrence has not been described anywhere within the literature.
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