• We have demonstrated that neuregulin induced proliferation o

  2018-10-20

  

  We have demonstrated that neuregulin-induced proliferation of differentiated adult mouse and rat cardiomyocytes occurs primarily in the mononucleated portion (Bersell et al., 2009). Most adult zebrafish cardiomyocytes are mononucleated, which is consistent with their significant proliferative activi

• To investigate whether PD derived HSCs

  2018-10-20

  

  To investigate whether PD-derived HSCs exist in other mammals, we analyzed the resident cells in the peritoneal cavity of C57BL/6 mice without any prior treatment. We found that there was a higher ratio (0.51±0.04%) of Lin−/Sca1+/c-kit+ population in the mouse peritoneal cavity than in bone marrow (

• g to mol calculator Mesenchymal stem cells MSCs can be isola

  2018-10-20

  

  Mesenchymal stem g to mol calculator (MSCs) can be isolated from various adult tissues (including bone marrow), they are multipotent and can differentiate into cells of the mesodermal (e.g. adipocytes, osteocytes, chondrocytes) as well as other embryonic lineages (Jiang et al., 2002). MSCs can also

• The present results demonstrate that GABP is important for m

  2018-10-20

  

  The present results demonstrate that GABP is important for myeloid differentiation confirming the recently reported observations by us and others in hematopoietic cell lines and murine models, respectively (Yang et al., 2011; Yu et al., 2011; Ripperger et al., 2015). Here, for the first time, human

• Interestingly in contrast to the common

  2018-10-20

  

  Interestingly, in contrast to the common roles of SNAI-1 and 2 in repressing E-cadherin mediated EMT, SNAI-1 is the only SNAI factor that is expressed in endoderm and Hep cells, and that instructs positively hepatic cell fate. The unique function of SNAI-1 compared to SNAI-2 was also noted during th

• Cy3-dCTP br Conclusions Seven days of induction to adipogeni

  2018-10-20

  

  Conclusions Seven days of induction to adipogenic differentiation promotes a transition from glycolytic metabolism to OXPHOS. During this period, induced Cy3-dCTP showed an increment in oxygen consumption, suggesting a stimulus for oxidative phosphorylation in these cells. The NPT concentration

• These results with fresh non fractionated

  2018-10-20

  

  These results with fresh, non-fractionated, not culture-expanded, adipose tissue-derived SVF are comparable with other two previously reported clinical series, using cultured adipose-derived ADSCs with controlled cell doses. The adipose tissue contains large populations of mesenchymal multidrug resi

• Using similar approach additional mESC lines could

  2018-10-20

  

  Using similar approach, additional mESC lines could be derived using a Pitx3::GFP reporter mouse (Zhao et al., 2004) and another aSYN mouse model of Parkinson\'s disease, expressing human WT SNCA (Westerlund et al., 2008) (data now shown). These mESC lines (Table 1) can be used to study human SNCA-

• calcifediol For ESCs on the other hand we and others recentl

  2018-10-20

  

  For ESCs, on the other hand, we and others recently established that single factors, such as neurogenic differentiation factor 1 (NEUROD1) or neurogenin 2 (NGN2), alone are sufficient to rapidly induce the neuronal fate (Thoma et al., 2012; Zhang et al., 2013). In fibroblasts, however, we had origin

• We propose that a quantitative

  2018-10-20

  

  We propose that a quantitative marker for tracking cardiac myocyte maturation resides in the developmentally controlled and irreversible (excepting targeted reprogramming) genetic switch in the sarcomeric TNNI gene. Owing to strict developmental control in all mammalian hearts, including humans, the

• The WNT signaling pathway is a primary determinant

  2018-10-20

  

  The WNT signaling pathway is a primary determinant in assigning an A/P positional identity to NPCs. This instructional cue is imparted early during NPC generation and once this identity is established, it is stable and cannot be altered through exogenous manipulation of the WNT pathway. Using a WNT

• br Experimental Procedures br Author

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Unlike the human prostate, which is organized into a single lobe with varying zonal layers, the murine prostate has four distinct lobes surrounding the urethra. The adult prostate contains three epithelial lineages

• Herein we describe increased VEGFA and SEMA A expression

  2018-10-20

  

  Herein, we describe increased VEGFA and SEMA3A expression in bone marrow akt inhibitor from de novo AML patients and the possible dominant effect of SEMA3A, suggesting that SEMA3A could control the effects caused by VEGFA. However, some questions remain: Why is SEMA3A expression increased in BMSCs f

• We believe that the production of homogeneous and functional

  2018-10-20

  

  We believe that the production of homogeneous and functional PSC-derived ventricular CMs using a non-transgenic approach will open new avenues for basic research and clinical applications. First, a pure population of ventricular CMs generated by the MB-based method offers a safer and more effective

• Recent studies indicate that the canonical

  2018-10-20

  

  Recent studies indicate that the canonical Wnt pathway affects BMSC osteogenic differentiation. Wnt signaling can promote osteoblastic precursor differentiation into more differentiated osteoblasts and can serve as a negative regulator of adipogenesis (Glass et al., 2005; Krishnan et al., 2006). Thi

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