• In summary our data show a novel mechanism CPD

  2021-08-23

  

  In summary, our data show a novel mechanism: CPD-mediated autoprocessing of C difficile toxins regulates their proinflammatory activities. Thus, our study provides a new understanding of the molecular mechanisms of the pathogenesis of C difficile toxins and insights into designing new therapeutics a

• br Neuroimaging Neuroimaging has not yet been systematically

  2021-08-23

  

  Neuroimaging Neuroimaging has not yet been systematically reported in individuals with CDD, although case reports document normal Eltrombopag mg anatomy or less often, show cortical atrophy or T2 fluid-attenuated inversion recovery hyperintensities in the white matter.15, 17, 18, 19, 48, 52, 54,

• In this study we characterized the metabolic

  2021-08-23

  

  In this study, we characterized the metabolic function of tra2 in the Drosophila fat body. Similar to the 9G8 phenotype, decreasing tra2 levels in the Drosophila fat body using RNAi resulted in increased starvation resistance and a large increase in triglycerides. This increased storage of triglycer

• Although many neurotransmitters e g catecholamines serotonin

  2021-08-23

  

  Although many neurotransmitters (e.g., catecholamines, serotonin, and excitatory/inhibitory amino acids) have been implicated in the modulation of anxiety-like responses (Carobrez et al., 2001, Molchanov and Guimaraes, 2002, Vianna et al., 2001), the so-called atypical neurotransmitters, endocannabi

• It was recently reported that

  2021-08-23

  

  It was recently reported that a functional single nucleotide polymorphism (rs75932628) within Triggering receptor expressed on myeloid Human HGF / Hepatocyte Growth Factor Protein 2 (TREM2) is associated with AD (Guerreiro et al., 2013). Homozygous loss of function mutations in TREM2 are also asso

• br Method br Results br Discussion In this

  2021-08-23

  

  Method Results Discussion In this cross-sectional study, we investigated the relationship between the COMT ValMet polymorphism and age on regional cortical thickness in healthy adults across the lifespan. The mesocortical pathway was of primary interest because of its projections from the v

• Bovine collagen type II a fibrillar collagen

  2021-08-23

  

  Bovine collagen type II, a fibrillar collagen mainly found in cartilage, comprises 24 potentially glycosylated lysine residues within its collagen domain. Detailed analysis revealed that 22 out of 23 of these lysine residues are hydroxylated and carry variable numbers of Gal(β1-O) and Glc(α1-2)Gal(β

• In general terms PLA s participate in the Lands

  2021-08-23

  

  In general terms, PLA2s participate in the Lands cycle of phospholipid fatty Phusion high-fidelity DNA polymerase recycling [1,15,25], whereby the fatty acid composition at the sn-2 position of phospholipids is tightly controlled by a balance between hydrolytic reactions mediated by PLA2s versus act

• br Conflict of interests br Introduction Ubiquitylation is

  2021-08-23

  

  Conflict of interests Introduction Ubiquitylation is a post-translational modification which impacts almost every biological process in the cell. Dysregulation of the ubiquitylation pathway is associated with several diseases, including cancer, neurodegenerative disorders, and immunological dy

• Saxagliptin One of the isolated interactors against Mulan Ub

  2021-08-23

  

  One of the isolated interactors against Mulan259–352–Ube2E3 fusion bait was found to be the GABARAP protein, a known member of the Atg8 family that includes LC3 [20]. The Atg8 family-of-proteins are major players in autophagy/mitophagy since they are part of the autophagosome [20], [21], [22]. Our s

• br Role of ALDH Isoenzymes in Glioma Growth

  2021-08-20

  

  Role of ALDH Isoenzymes in Glioma Growth and Invasion ALDH family genes are commonly upregulated in gliomas, indicating ALDH-dependent cell metabolism. Specific ALDH isoenzymes have been detected in high- and low-grade tumors implicated in cell proliferation, maintenance of CSC properties, invasi

• BIX 02565 br Conclusion br Funding source

  2021-08-20

  

  Conclusion Funding source Ethical approval Conflict of interest statement Introduction Traditionally, schizophrenia (SZ) was thought to be associated with neuronal dysfunction; however, the current hypothesis that myelin and, specifically, oligodendrocytes are also involved in the dev

• Previous and ongoing clinical trials

  2021-08-20

  

  Previous and ongoing clinical trials have been summarized in a recent review (Siaw-Debrah et al., 2017). To our knowledge, there are no ongoing or completed clinical trials focusing on cytokines in ICH. Published studies have focused mainly on cytokine changes in ICH patients (summarized in Table 3)

• salt inducible kinase The CysLT receptor antagonist BayCysLT

  2021-08-20

  

  The CysLT2 receptor antagonist BayCysLT2RA significantly suppressed multiple antigen challenge-induced infiltration of eosinophils and mononuclear salt inducible kinase into the lung, indicating that CysLT2 receptor activation is involved in leukocyte migration. In contrast to the present finding,

• Injurious effects of cigarette smoke CS on human health

  2021-08-20

  

  Injurious effects of cigarette smoke (CS) on human health are progressively being acknowledged both in animal and human studies. CS is a highly complex mixture that contains substantive amounts of toxic oxidants, nitric oxide, organic compounds, free radicals and microbial cell components including

16190 records 603/1080 page Previous Next First page 上5页 601602603604605 下5页 Last page