• Through the analysis of various synthetic GPR agonists as re

  2022-04-01

  

  Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic DIDS motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early period of discovering TAK-875

• br Materials and methods br Results

  2022-04-01

  

  Materials and methods Results Conclusions In general, the drug design process is very laborious, expensive and prone to errors. Various computational methods including docking and algorithms based on molecular dynamics and/or quantum chemistry can help considerably at the early stage of str

• Acknowledgments br Introduction Stress plays a key role in t

  2022-04-01

  

  Acknowledgments Introduction Stress plays a key role in the etiology and/or exacerbation of major depressive disorder characterized by loss of energy, feelings of hopelessness and anhedonia [1]. Ample evidence clearly suggests that endocannabinoids (eCBs) participate in stress-associated neurona

• Endotoxin induced pulmonary hypertension is a

  2022-04-01

  

  Endotoxin induced-pulmonary Ritonavir receptor is a reproducible finding in various animal models Leeper-Woodford et al., 1991, Weitzberg et al., 1993 and is also a feature of human sepsis where it may affect right ventricular function (Vincent, 1998). Mechanisms such as vasoconstriction and leukoc

• In this study there is a

  2022-03-31

  

  In this study, there is a limitation in the study of sex differences. Only female rats were used in our study. This is because the rats cannot urinate autonomously after SCI. Manual Y-27632 emptying was needed until reflex bladder emptying was established (Lu et al., 2008, Ma et al., 2015). Because

• In addition to acting as the gatekeeper for the metabolic

  2022-03-31

  

  In addition to acting as the gatekeeper for the metabolic and antioxidant roles of glucose, HKs have also been found to regulate mPTP opening directly. First described in the cancer field, the high-affinity HK isoforms HK1 and HK2 are strongly anti-apoptotic when bound to the outer mitochondrial mem

• Introduction Hedgehog HH signaling regulates development cel

  2022-03-31

  

  Introduction Hedgehog (HH) signaling regulates development, cell proliferation, and tissue repair [1], [2], [3]. In mammals, HH signaling is activated by 3 ligands: Sonic hedgehog (SHH), Indian hedgehog (IHH), or Desert hedgehog; SHH is the most widely expressed in adult tissues [3]. The primary re

• Finally we find that in the absence of Aurora

  2022-03-31

  

  Finally, we find that in the absence of Aurora B, Sgo1 is delocalized from centromeres and found along chromosome arms, as reported after depletion of Bub1 (Kitajima et al., 2005, Riedel et al., 2006). The increased arm cohesion observed in the absence of Aurora B activity is dependent on the presen

• The fibulins are a newly abundantly in

  2022-03-31

  

  The fibulins are a newly abundantly in the basement membrane of blood vessels. Among them, fibulin-1 is essential for elastin polymerization. Tropoelastin cannot be assembled into mature elastin fibrils without the functional fibulin-1. In adult blood vessels, pronounced fibulin 1 deposition can be

• Curcumin is a major yellow

  2022-03-31

  

  Curcumin is a major yellow pigment in turmeric ground rhizome of Curcuma longa Linn, which is used widely as a spice and coloring agent in several foods such as curry, mustard and potato chips as well as cosmetics and drugs (Okada et al., 2001, Joe et al., 2004). Curcumin represents a class of anti-

• ephrin receptor br GSNOR regulates SA synthesis and SA signa

  2022-03-31

  

  GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic ephrin receptor (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal resi

• GPR is a member of the G protein coupled receptor

  2022-03-31

  

  GPR119 is a member of the G protein-coupled receptor family, and is highly expressed in pancreatic β-cells and intestinal endocrine cells. It has been proposed that GPR119 agonists modulate glucose homeostasis by indirectly stimulating glucose-dependent insulin release through enhancing pancreatic c

• Restless running behavior was first

  2022-03-31

  

  ‘Restless running behavior’ was first described in mice after administration of 30mg/kg i.p. ALX-5407 and was thought to be due to an augmentation of NMDA-induced dopamine activity [27]. The motor impairments caused by ALX-5407 were confirmed by Perry et al. [10] and extended to another sarcosine-de

• br Materials and methods br Results br Discussion The

  2022-03-31

  

  Materials and methods Results Discussion The redox domain that spans the region between amino SYN-117 positions 35 and 127 of the major human AP endonuclease, APE1, regulates the sequence-specific DNA binding of various transcription factors [[52], [85]]. The existent crystal structures of

• This resembles a vicious cycle since BBB disruption and infl

  2022-03-31

  

  This resembles a vicious cycle since BBB disruption and inflammation are thought to be caused by epilepsy, but other contributing factors are also known to be their cause, such as peripheral infection, autoimmunity, Sulfo-NHS-LC-Biotin mg trauma and stroke that also underlie epilepsy [18]. Addition

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