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Free fatty acids FFAs which
2022-01-03
Free fatty acids (FFAs), which are obtained from dietary fat or endogenous synthesis, function as nutrients and signaling molecules. Studies have shown that free fatty parp apoptosis pathway receptors 1–4 which are G-protein coupled receptors, bind free fatty acids and serve as receptors for these
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br Results br Discussion Impaired BBB functions evoke vasoge
2022-01-03
Results Discussion Impaired BBB functions evoke vasogenic edema, which elevates intracranial pressure and leads to a life-threatening condition (Sperk, 1994, Unterberg et al., 2004, Simard et al., 2007). In addition, vasogenic edema formation results in the worsen consequence contributing to p
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This connection is supported by studies in the SIV
2022-01-03
This connection is supported by studies in the SIV macaque model of HIV, where treatment with methamphetamine, which greatly enhances CNS dopamine levels (Truong, 2005); increased 16,16-Dimethyl Prostaglandin E2 viral load. Methamphetamine also increased expression of the HIV co-receptor CCR5 in CNS
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Obesity is one of the
2022-01-03
Obesity is one of the worldwide concerns, with high prevalence and adverse effects on human health and life expectancy. According to the World Health Organization (WHO), obesity is defined as abnormal or excessive fat accumulation in the body with body mass index (BMI) of 30 or more. Obesity increas
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Another level of complexity within the
2022-01-03
Another level of complexity within the TGF-ß/SMAD and Hippo/YAP/TAZ pathway crosstalks was recently uncovered. TGF-ß induces robust TAZ, but not YAP, protein expression in both mesenchymal and epithelial Cilengitide through a SMAD3-independent, p38/MAPK-dependent mechanism that triggers myocardin-re
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PR-619 ANT located in the IMM
2022-01-03
ANT, located in the IMM, mediates the exchange of ATP/ADP between the mitochondrial matrix and the intermembrane space (IMS) (Brand et al., 2005; Palmieri and Pierri, 2010). Of the 4 known isoforms, ANT1 is the dominant isoform in the heart (Palmieri and Pierri, 2010). Under physiological conditions
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