• In this work we developed multiple tools

  2018-11-08

  

  In this work, we developed multiple tools to interrogate this autocrine and paracrine signaling loop involving α-5 laminin production by hPSCs. The use of the inducible short hairpin lines allowed us to control the dynamics of α-5 laminin production in a reversible manner. However, the interpretatio

• A question arising from this work is

  2018-11-08

  

  A question arising from this work is whether development sets the stage for the early pathophysiological abnormalities in HD and whether we can identify candidate pathways or genes that will restore neuronal homeostasis and protect striatal MSNs halting disease progression. We believe the black and

• While we only implemented ArrayEdit

  2018-11-08

  

  While we only implemented ArrayEdit for fluorescence loss and growth rate differences, the method employing HCA is extendable in principle to any image-based phenotype. Phenotypes could be defined by changes in uptake of cytoxicity dyes, live immunocytochemistry for cell surface or extracellular mat

• folate analogue This has important implications for competit

  2018-11-08

  

  This has important implications for competitive transplantation experiments. Because they have the same reconstitution potential, modified HSPCs from any C57BL/6N or C57BL/6J strain can be directed compared with our CD45.1STEM strain without an additional control group. This contrasts with the situa

• Conversely short and long SD could be

  2018-11-07

  

  Conversely, short and long SD could be a result of poor SRH. One third of the older adult population has extreme SD (short or long) and presents difficulties in sleep onset and maintenance or has daytime sleepiness [7,26]. A prospective observational study of adults ages 40–64 found no evidence that

• The results of the hierarchical regression suggest that coun

  2018-11-07

  

  The results of the hierarchical regression suggest that countries with higher mean years of schooling are less likely to report positive vaccine sentiment, however within a country those with some education hold more positive views on vaccine importance, effectiveness, and religious compatibility (t

• This study has important limitations First

  2018-11-07

  

  This study has important limitations. First, participants came from one academic medical center with its own patterns of clinic attendance, which may limit generalizability. The results may also differ by surgical specialty, which would be an interesting avenue for future investigation. Second, the

• The clinical heterogeneity in AOS patients

  2018-11-07

  

  The clinical heterogeneity in AOS patients makes it difficult to study SMAD3 mutational effects on aneurysm formation. Fortunately, due to the homogenous genetic background, genetically engineered mouse models are useful in pinpointing the specific molecular mechanism leading to disease. Smad3 knock

• The ZIKV field is still developing and critics regarding the

  2018-11-07

  

  The ZIKV field is still developing, and critics regarding the use of the original ZIKV strain are starting to emerge. There is currently no appropriate African and Asian reference strains to allow proper comparison of results between laboratories. At this stage, we cannot disregard that the differen

• br Introduction MicroRNA miRNAs are a class

  2018-11-07

  

  Introduction MicroRNA (miRNAs) are a class of endogenous and non-coding single-stranded RNAs of approximately 22 nucleotides (Bartel, 2004), many of which are evolutionarily conserved (Farh et al., 2005). Nucleotides 2–7, from the 5′ end of the miRNA, are referred to as the seed sequence and are

• In the present study we took

  2018-11-07

  

  In the present study, we took advantage of the IVF procedure to focus on the imprinting alteration in oocyte before fertilization. Analysis in human showed that expression of IGF2, an acknowledged maternal imprinted gene responsible for β-cell function, was increased in oocytes from patients with hy

• LPL is the rate limiting enzyme in hydrolysis of TG

  2018-11-07

  

  LPL is the rate-limiting enzyme in hydrolysis of TG in TG-rich lipoproteins, and LPL activity is inversely correlated with plasma TG levels (Shimizugawa et al., 2002). Support for the second mechanism linking ABCA1 and plasma TG rests on the observations that TD subjects exhibit decreased LPL activi

• Exposure to specific environmental factors

  2018-11-07

  

  Exposure to specific environmental factors increases the risk to develop schizophrenia in vulnerable individuals (van Os et al., 2010), thus environmental and genetic factors may both influence age at illness onset in schizophrenia. Accumulated exposures such as obstetric complications, trauma, urba

• Limitations of this study relate to

  2018-11-07

  

  Limitations of this study relate to the lack of cord, blood and adipose tissue from the same individuals, so we cannot extrapolate how CDKN2A methylation in cord tissue may relate to the methylation of CDKN2A in adipose or blood in the same individual, and/or whether such epigenetic alterations are

• The first SCAPs were identified through expression profiling

  2018-11-07

  

  The first SCAPs were identified through expression profiling of senescent vs. non-senescent human transferase and confirmed in RNA interference studies (Zhu et al., 2015b). The pathways included networks related to BCL-2/BCL-XL, PI3K/AKT, p53/p21/serpines, dependence receptors/tyrosine kinases, and

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